We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.
Do you want to read the rest of this article? We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. For further information, including about cookie settings, please read our Cookie Policy. By continuing to use this site, you consent to the use of cookies.
We value your privacy. Download citation. Request full-text. A 'read' is counted each time someone views a publication summary such as the title, abstract, and list of authors , clicks on a figure, or views or downloads the full-text. Learn more. Source: PubMed. Show more authors. The most prevalent antibodies were directed against HSV-2 9 cases, i. Citations 5. References HSV type 2 HSV-2 causes genital diseases and neonatal infections through a maternal genital tract to the newborn Pellet and Roizman, Genital herpes caused by HSV-2 is one of the most important sexually transmitted diseases Bystrick?
Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. Full-text available. Mar Acta Virol. In addition, it is known that nectin-2 is also functional as a receptor for HSV-2, although the binding to the gD is weak. To examine an antiviral potential of a soluble form of human nectin-2 hNectin-2Ig , transfected Vero cells expressing the entire ectodomain of nectin-2 fused to the Fc portion of human IgG were established.
Competitive ELISA demonstrated that accumulation of hNectin-2Ig in transfected cells increased significantly in a cell culture time dependent manner. Viral growth of several HSV-2 strains was significantly inhibited in the transfected cells that were cultured for 72 hr compared with control Vero cells, but not in cells that were cultured for 24 hr. These results indicate that accumulation of a soluble form of nectin-2 is required for exerting the resistance against HSV-2 infection.
